Across TCGA patient cohorts, ZNRF1 protein abundance is significantly associated with the RNA expression of many other genes, with 3,844 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ZNRF1-associated genes across cancer lineages are BTN2A2, RASSF5, and TLR8. Each is linked with ZNRF1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNRF1-to-partner and partner-to-ZNRF1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNRF1→partner) and Y-score (partner→ZNRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	BTN2A2 →	-0.784	-0.402	<.001	<.001	3	4
BRCA	RASSF5 →	-0.811	-0.629	.001	.005	3	3
LSCC	TLR8 →	-0.812	-0.290	<.001	.001	3	3
BRCA	TNFSF13B →	-0.928	-0.582	<.001	.004	3	3
HNSC	NUB1 →	-0.620	-0.421	.002	.002	3	3
HNSC	SLAIN1 →	-1.468	-0.476	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,844 associations by consensus.

Exploration

ZNRF1 survival (RNA) · tumor vs normal (RNA) · all ZNRF1 data types