Across TCGA patient cohorts, ZNRF1 mutation is significantly associated with the RNA expression of many other genes, with 1,706 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNRF1-associated genes across cancer lineages are RNA5SP414, RNA5SP410, and MIR5787. Each is linked with ZNRF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNRF1-to-partner and partner-to-ZNRF1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNRF1→partner) and Y-score (partner→ZNRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP414 →	+0.478	+2.139	<.001	.005	3	2
UCEC	RNA5SP410 →	+0.453	+2.011	.005	.005	3	2
BRCA	MIR5787 →	+0.588	+6.215	<.001	.001	3	1
BRCA	RNA5SP416 →	+0.669	+7.471	<.001	.008	3	1
BRCA	RN7SL217P →	+0.266	+6.162	<.001	.002	3	1
UCEC	MAPK1 →	+0.608	+2.807	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,706 associations by consensus.

Exploration

ZNRF1 survival (RNA) · tumor vs normal (RNA) · all ZNRF1 data types