ZNRD2

Across TCGA pan-cancer cohorts, ZNRD2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZNRD2 data layer compared with 28 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ZNRD2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ZNRD2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, HNSC, and LUAD are the cancer types where ZNRD2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	III,IV	1.000	0.261	.006	20	view →
HNSC	DFS	Tertile	All	0.949	0.528	.018	19	view →
LUAD	DFS	Quartile	III,IV	0.949	0.264	.006	11	view →
CCRCC	DFS	Median	III,IV	0.821	1.000	.020	7	view →
PDAC	OS	Quartile	II,III,IV	0.958	0.647	.034	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ZNRD2–UCEC (DFS)

Open the UCEC breakdown →