ZNHIT6

Across TCGA patient cohorts, ZNHIT6 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNHIT6-associated genes across cancer lineages are EGFR_pY1068, p62 Lck ligand, and eIF4E. Each is linked with ZNHIT6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNHIT6-to-partner and partner-to-ZNHIT6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ZNHIT6-low versus ZNHIT6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNHIT6→partner) and Y-score (partner→ZNHIT6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.227	-2.321	.039	.034	3	2
UCEC	p62 Lck ligand →	+0.495	+2.807	<.001	.003	3	2
UCEC	eIF4E →	+0.223	+3.183	.015	.009	3	1
UCEC	Heregulin →	-0.117	-2.115	.030	.019	3	1
UCEC	MEK1 →	+0.384	+2.584	.016	.010	3	1
UCEC	PDK1_pS241 →	+0.190	+3.026	.011	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

EGFR_pY1068 by ZNHIT6 expression — UCEC

Explore this box plot interactively →