ZNHIT3

Across TCGA patient cohorts, ZNHIT3 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNHIT3-associated genes across cancer lineages are JNK2, p90 RSK, and Rab25. Each is linked with ZNHIT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNHIT3-to-partner and partner-to-ZNHIT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by ZNHIT3-low versus ZNHIT3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNHIT3→partner) and Y-score (partner→ZNHIT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.274	+3.179	.004	.010	3	1
UCEC	p90 RSK →	+0.190	+2.179	.039	.034	3	1
UCEC	Rab25 →	-0.397	-2.459	.013	.020	3	1
UCEC	Annexin-1 →	+0.627	+2.999	.013	.035	3	1
UCEC	Shc_pY317 →	-0.204	-2.459	.005	.020	3	1
UCEC	ATM →	-0.626	-2.986	.004	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

JNK2 by ZNHIT3 expression — UCEC

Explore this box plot interactively →