ZNHIT2

Across TCGA cell cohorts, ZNHIT2 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible ZNHIT2-associated genes across cancer lineages are KRTAP17-1, OPRPN, and TRIML1. Each is linked with ZNHIT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNHIT2-to-partner and partner-to-ZNHIT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP17-1 grouped by ZNHIT2-low versus ZNHIT2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNHIT2→partner) and Y-score (partner→ZNHIT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KRTAP17-1 →	+0.025	+4.977	<.001	.007	3	1
BREAST	OPRPN →	+0.745	+4.781	<.001	.003	3	1
BREAST	TRIML1 →	+0.312	+4.421	<.001	.004	3	1
BREAST	RNASE9 →	+0.010	+4.781	<.001	.003	3	1
LARGE_INTESTINE	OR13G1 →	+0.024	+4.415	<.001	.007	3	1
LARGE_INTESTINE	GSG1L2 →	+0.020	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

KRTAP17-1 by ZNHIT2 expression — SKIN

Explore this box plot interactively →