ZNHIT1

Across TCGA pan-cancer cohorts, ZNHIT1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZNHIT1 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ZNHIT1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ZNHIT1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD, PDAC, and HNSC are the cancer types where ZNHIT1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	II,III,IV	1.000	0.287	.013	11	view →
PDAC	DFS	Tertile	III,IV	0.872	0.283	.024	6	view →
HNSC	OS	Median	II,III,IV	1.000	0.952	.023	4	view →
LSCC	OS	Median	II,III,IV	0.887	0.710	.039	1	view →
CCRCC	OS	Median	All	0.741	1.000	.027	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ZNHIT1–LUAD (OS)

Open the LUAD breakdown →