ZNHIT1

Across TCGA patient cohorts, ZNHIT1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNHIT1-associated genes across cancer lineages are Annexin-1, c-Jun_pS73, and Cyclin-B1. Each is linked with ZNHIT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNHIT1-to-partner and partner-to-ZNHIT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by ZNHIT1-low versus ZNHIT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNHIT1→partner) and Y-score (partner→ZNHIT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.750	+2.341	.002	.019	3	2
UCEC	c-Jun_pS73 →	-0.171	-2.584	.021	.011	3	2
UCEC	Cyclin-B1 →	+0.680	+2.584	.009	.011	3	2
UCEC	EGFR_pY1068 →	-0.358	-2.584	.002	.011	3	1
UCEC	A-Raf_pS299 →	-0.166	-3.000	.002	.036	3	1
UCEC	FOXO3a_pS318_S321 →	-0.125	-3.160	.032	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Annexin-1 by ZNHIT1 expression — UCEC

Explore this box plot interactively →