ZNFX1

Across TCGA pan-cancer cohorts, ZNFX1 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated ZNFX1 data layer compared with 25 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ZNFX1 Mutation is associated with better overall survival. In most high-consensus cancer types, elevated ZNFX1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and CESC show a favorable association.

UCEC, SARC, and BRCA are the cancer types where ZNFX1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	0.961	0.642	.004	26	view →
SARC	OS	Median	All	0.274	0.749	<.001	15	view →
BRCA	OS	Median	III,IV	0.609	0.906	.002	10	view →
LGG	OS	Median	All	0.219	0.889	<.001	6	view →
HNSC	OS	Median	IV	0.059	0.642	.004	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
ESCA	DFS	Median	All	0.146	0.533	.046	3	view →
CESC	DFS	Median	All	1.000	0.520	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

ZNFX1–UCEC (OS)

Open the UCEC breakdown →