ZNFX1

Across TCGA patient cohorts, ZNFX1 mutation is significantly associated with the RNA expression of many other genes, with 4,471 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNFX1-associated genes across cancer lineages are GPR3, SRPRB, and LRRC43. Each is linked with ZNFX1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNFX1-to-partner and partner-to-ZNFX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR3 grouped by ZNFX1-low versus ZNFX1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNFX1→partner) and Y-score (partner→ZNFX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	GPR3 →	+0.805	+3.331	.004	.005	3	4
UCEC	SRPRB →	+0.314	+1.517	<.001	<.001	3	4
COAD	LRRC43 →	-0.431	-3.544	.007	.003	3	3
CESC	GAPDHP34 →	+0.015	+3.994	<.001	.007	3	3
UCEC	EIF4E →	+0.326	+2.222	<.001	<.001	3	3
UCEC	HSPA4L →	+0.576	+1.255	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,471 associations by consensus.

GPR3 by ZNFX1 expression — CESC

Explore this box plot interactively →