ZNFX1

Across TCGA patient cohorts, ZNFX1 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNFX1-associated genes across cancer lineages are Caspase-7-cleavedD198, Notch1, and Shc_pY317. Each is linked with ZNFX1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNFX1-to-partner and partner-to-ZNFX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ZNFX1-low versus ZNFX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNFX1→partner) and Y-score (partner→ZNFX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.585	+2.341	<.001	<.001	3	4
UCEC	Notch1 →	+0.136	+1.536	<.001	.003	3	3
UCEC	Shc_pY317 →	-0.101	-0.866	.011	.045	3	3
UCEC	ATM →	-0.445	-2.794	<.001	<.001	3	3
UCEC	c-Met →	-0.179	-2.249	.022	<.001	3	3
UCEC	Di-Ras3 →	-0.133	-2.124	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

Caspase-7-cleavedD198 by ZNFX1 expression — UCEC

Explore this box plot interactively →