ZNF92

Across TCGA patient cohorts, ZNF92 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF92-associated genes across cancer lineages are eIF4E, ACC1, and MEK1. Each is linked with ZNF92 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF92-to-partner and partner-to-ZNF92 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ZNF92-low versus ZNF92-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF92→partner) and Y-score (partner→ZNF92) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.215	+2.523	.002	<.001	3	2
UCEC	ACC1 →	+0.264	+1.700	.033	.042	3	2
UCEC	MEK1 →	+0.465	+3.906	<.001	<.001	3	2
UCEC	p70-S6K_pT389 →	-0.161	-1.807	.013	.024	3	2
UCEC	PKC-a_pS657 →	-0.298	-1.797	.022	.025	3	2
STAD	14-3-3_zeta →	+0.389	+3.000	.015	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

eIF4E by ZNF92 expression — UCEC

Explore this box plot interactively →