Across TCGA patient cohorts, ZNF883 mutation is significantly associated with the RNA expression of many other genes, with 1,105 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF883-associated genes across cancer lineages are CENPH, SKA1, and WASF2. Each is linked with ZNF883 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF883-to-partner and partner-to-ZNF883 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF883→partner) and Y-score (partner→ZNF883) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CENPH →	+0.703	+2.592	<.001	<.001	3	2
SKCM	SKA1 →	+0.744	+2.719	.001	.003	3	2
UCEC	WASF2 →	+0.415	+2.008	.005	.005	3	2
UCEC	PEF1 →	+0.294	+2.491	.003	<.001	3	2
UCEC	POC1A →	+0.519	+1.923	.004	.009	3	2
UCEC	AKIP1 →	+0.428	+3.111	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,105 associations by consensus.

Exploration

ZNF883 survival (RNA) · tumor vs normal (RNA) · all ZNF883 data types