Across TCGA patient cohorts, ZNF883 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF883-associated genes across cancer lineages are JNK_pT183_Y185, PDCD4, and 4E-BP1. Each is linked with ZNF883 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF883-to-partner and partner-to-ZNF883 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF883→partner) and Y-score (partner→ZNF883) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.174	-1.906	.004	.015	3	2
UCEC	PDCD4 →	-0.500	-2.115	.003	.016	3	2
UCEC	4E-BP1 →	+0.248	+2.489	.012	.010	3	2
UCEC	EGFR_pY1068 →	-0.238	-2.321	.009	.033	3	1
UCEC	eIF4E →	+0.202	+3.598	.009	.001	3	1
UCEC	A-Raf_pS299 →	-0.106	-2.700	.015	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Exploration

ZNF883 survival (RNA) · tumor vs normal (RNA) · all ZNF883 data types