ZNF878

Across TCGA patient cohorts, ZNF878 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF878-associated genes across cancer lineages are STAT3_pY705, 14-3-3_beta, and EGFR_pY1068. Each is linked with ZNF878 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF878-to-partner and partner-to-ZNF878 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by ZNF878-low versus ZNF878-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF878→partner) and Y-score (partner→ZNF878) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.302	-1.838	<.001	.007	3	2
UCEC	14-3-3_beta →	-0.082	-2.558	.015	.010	3	1
UCEC	EGFR_pY1068 →	-0.219	-2.087	.009	.005	3	1
UCEC	A-Raf_pS299 →	-0.084	-1.807	.035	.025	3	1
UCEC	ACC1 →	+0.287	+1.750	.018	.049	3	1
UCEC	Ku80 →	+0.248	+1.598	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

STAT3_pY705 by ZNF878 expression — UCEC

Explore this box plot interactively →