ZNF878

Across TCGA cell cohorts, ZNF878 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF878-associated genes across cancer lineages are USP26, KRTAP16-1, and NPVF. Each is linked with ZNF878 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF878-to-partner and partner-to-ZNF878 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP26 grouped by ZNF878-low versus ZNF878-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF878→partner) and Y-score (partner→ZNF878) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	USP26 →	+0.050	+4.237	<.001	.006	3	1
PANCREAS	KRTAP16-1 →	+0.017	+4.614	<.001	.004	3	1
SKIN	NPVF →	+0.015	+3.345	<.001	.007	3	1
SKIN	POU4F2 →	+0.471	+3.584	<.001	.007	3	1
SKIN	TDGF1 →	+0.245	+4.206	<.001	.001	3	1
BLOOD_Leukemia	IFNA4 →	+0.024	+4.922	.009	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

USP26 by ZNF878 expression — PANCREAS

Explore this box plot interactively →