ZNF875

Across TCGA patient cohorts, ZNF875 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF875-associated genes across cancer lineages are EGFR_pY1068, MEK1, and Rad50. Each is linked with ZNF875 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF875-to-partner and partner-to-ZNF875 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ZNF875-low versus ZNF875-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF875→partner) and Y-score (partner→ZNF875) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.207	-2.321	.046	.006	3	2
UCEC	MEK1 →	+0.469	+3.459	.001	.005	3	2
UCEC	Rad50 →	-0.243	-1.807	.015	.027	3	2
UCEC	Caspase-8 →	-0.254	-3.432	.014	.005	3	2
UCEC	c-Jun_pS73 →	-0.140	-2.986	.033	.035	3	2
UCEC	Cyclin-B1 →	+0.649	+3.000	.005	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

EGFR_pY1068 by ZNF875 expression — UCEC

Explore this box plot interactively →