ZNF875

Across TCGA cell cohorts, ZNF875 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF875-associated genes across cancer lineages are TBC1D3H, OR10H5, and ADRA1A. Each is linked with ZNF875 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF875-to-partner and partner-to-ZNF875 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D3H grouped by ZNF875-low versus ZNF875-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF875→partner) and Y-score (partner→ZNF875) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TBC1D3H →	+0.023	+4.643	<.001	.008	3	1
LUNG_SCLC	OR10H5 →	+0.047	+4.044	.006	.009	3	1
BLOOD_Leukemia	ADRA1A →	+0.110	+3.121	.003	.003	3	1
BLOOD_Leukemia	AQP4 →	+0.100	+4.153	<.001	<.001	3	1
BLOOD_Leukemia	TEX48 →	+0.028	+3.475	<.001	.001	3	1
LARGE_INTESTINE	SLC25A19 →	+0.589	+3.064	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

TBC1D3H by ZNF875 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →