ZNF853

Across TCGA patient cohorts, ZNF853 mutation is significantly associated with the RNA expression of many other genes, with 148 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF853-associated genes across cancer lineages are SNORD116-10, MIR4282, and RNU6-965P. Each is linked with ZNF853 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF853-to-partner and partner-to-ZNF853 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD116-10 grouped by ZNF853-low versus ZNF853-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF853→partner) and Y-score (partner→ZNF853) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNORD116-10 →	+0.309	+3.598	<.001	.002	3	3
UCEC	MIR4282 →	+0.165	+4.276	.003	.005	3	2
UCEC	RNU6-965P →	+0.306	+4.601	<.001	.003	3	2
UCEC	RNA5SP437 →	+0.537	+2.985	<.001	<.001	3	2
COAD	RNU6-1234P →	+0.345	+4.962	.001	.003	3	2
COAD	MTND2P17 →	+0.055	+5.557	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 148 associations by consensus.

SNORD116-10 by ZNF853 expression — UCEC

Explore this box plot interactively →