ZNF853

Across TCGA cell cohorts, ZNF853 mutation is significantly associated with the mutation status of many other genes, with 1,918 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF853-associated genes across cancer lineages are COL15A1, DISP3, and CHD7. Each is linked with ZNF853 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF853-to-partner and partner-to-ZNF853 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COL15A1 grouped by ZNF853-low versus ZNF853-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF853→partner) and Y-score (partner→ZNF853) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	COL15A1 →	+3.584	+3.584	.006	.006	1	3
STOMACH	DISP3 →	+4.584	+3.942	.002	.002	1	3
LUNG_NSCLC_LUAD	CHD7 →	+3.117	+4.491	.004	.004	1	3
LARGE_INTESTINE	NOS1 →	+1.691	+2.479	.008	.008	1	3
LUNG_SCLC	APLP1 →	+4.502	+5.066	.007	.007	1	3
LUNG_SCLC	ARHGAP22 →	+4.502	+5.066	.007	.007	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,918 associations by consensus.

COL15A1 by ZNF853 expression — STOMACH

Explore this box plot interactively →