ZNF853

Across TCGA cell cohorts, ZNF853 mutation is significantly associated with the drug of many other genes, with 35 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF853-associated genes across cancer lineages are AZD8055, 50869, and Zibotentan. Each is linked with ZNF853 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF853-to-partner and partner-to-ZNF853 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AZD8055 grouped by ZNF853-low versus ZNF853-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF853→partner) and Y-score (partner→ZNF853) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AZD8055 →	+0.559	+2.807	.020	.046	3	1
LARGE_INTESTINE	50869 →	+0.402	+2.871	.045	.021	3	1
LARGE_INTESTINE	Zibotentan →	+0.192	+2.874	.046	.021	3	1
LARGE_INTESTINE	KIN001-244 →	+0.383	+2.807	.048	.026	3	1
LARGE_INTESTINE	Torin 2 →	+0.569	+2.877	.025	.020	3	1
LARGE_INTESTINE	ETP-45835 →	+0.283	+2.874	.012	.021	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

AZD8055 by ZNF853 expression — LARGE_INTESTINE

Explore this box plot interactively →