ZNF852

Across TCGA patient cohorts, ZNF852 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF852-associated genes across cancer lineages are A-Raf_pS299, ERK2, and GATA6. Each is linked with ZNF852 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF852-to-partner and partner-to-ZNF852 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by ZNF852-low versus ZNF852-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF852→partner) and Y-score (partner→ZNF852) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.121	-2.584	.004	.010	3	1
UCEC	ERK2 →	+0.164	+1.584	.018	.019	3	1
UCEC	GATA6 →	-0.136	-1.670	.021	.022	3	1
UCEC	MEK1 →	+0.409	+2.906	.001	.001	3	1
UCEC	MSH2 →	-0.204	-2.295	.014	.033	3	1
UCEC	N-Ras →	-0.097	-2.302	.023	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

A-Raf_pS299 by ZNF852 expression — UCEC

Explore this box plot interactively →