ZNF850

Across TCGA patient cohorts, ZNF850 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF850-associated genes across cancer lineages are S6_pS240_S244, ATM, and eEF2. Each is linked with ZNF850 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF850-to-partner and partner-to-ZNF850 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S6_pS240_S244 grouped by ZNF850-low versus ZNF850-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF850→partner) and Y-score (partner→ZNF850) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	S6_pS240_S244 →	+0.291	+1.473	.019	.006	3	2
UCEC	ATM →	-0.542	-2.571	<.001	<.001	3	2
UCEC	eEF2 →	+0.255	+1.807	.020	.024	3	1
UCEC	EGFR_pY1068 →	-0.279	-2.222	<.001	<.001	3	1
UCEC	eIF4E →	+0.219	+1.947	<.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.118	-2.247	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

S6_pS240_S244 by ZNF850 expression — UCEC

Explore this box plot interactively →