ZNF843

Across TCGA patient cohorts, ZNF843 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF843-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and JNK2. Each is linked with ZNF843 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF843-to-partner and partner-to-ZNF843 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ZNF843-low versus ZNF843-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF843→partner) and Y-score (partner→ZNF843) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.801	+2.479	.001	.010	3	2
UCEC	EGFR_pY1068 →	-0.307	-2.807	.005	.003	3	1
UCEC	JNK2 →	+0.206	+2.115	.017	.019	3	1
UCEC	Ku80 →	+0.302	+2.820	.003	.001	3	1
UCEC	p62 Lck ligand →	+0.388	+3.469	.006	.002	3	1
UCEC	PDK1_pS241 →	+0.183	+2.820	.014	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Caspase-7-cleavedD198 by ZNF843 expression — UCEC

Explore this box plot interactively →