Across TCGA patient cohorts, ZNF84 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF84-associated genes across cancer lineages are p38-MAPK_pT180_Y182, C-Raf, and 14-3-3_beta. Each is linked with ZNF84 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF84-to-partner and partner-to-ZNF84 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF84→partner) and Y-score (partner→ZNF84) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.300	-1.440	.023	.022	3	2
UCEC	C-Raf →	+0.137	+1.637	.001	.001	3	2
UCEC	14-3-3_beta →	-0.082	-2.388	.005	.002	3	1
UCEC	EGFR_pY1068 →	-0.185	-1.514	.012	.014	3	1
UCEC	EGFR →	-0.094	-1.058	.046	.037	3	1
UCEC	eIF4E →	+0.135	+1.502	.029	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Exploration

ZNF84 survival (RNA) · tumor vs normal (RNA) · all ZNF84 data types