ZNF84-DT

Across TCGA pan-cancer cohorts, ZNF84-DT RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ZNF84-DT data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ZNF84-DT RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF84-DT expression acts as an unfavorable survival marker, although some lineages such as UCS and THYM show a favorable association.

KIRC, LGG, and UCS are the cancer types where ZNF84-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.760	0.843	.005	54	view →
LGG	OS	Median	All	0.754	0.867	<.001	46	view →
UCS	DFS	Tertile	II,III,IV	0.609	0.141	.002	40	view →
KICH	OS	Tertile	All	0.622	0.963	.003	35	view →
HNSC	DFS	Tertile	All	0.528	0.659	.009	35	view →
LIHC	DFS	Tertile	All	0.174	0.331	.005	27	view →
THCA	OS	Tertile	II,III,IV	0.723	1.000	.013	25	view →
PAAD	DFS	Tertile	All	0.359	0.564	.007	20	view →
THYM	DFS	Tertile	II,III,IV	1.000	0.830	.010	15	view →
SARC	OS	Median	All	0.670	0.784	.017	15	view →
OV	DFS	Quartile	IV	0.487	0.204	.006	12	view →
MESO	OS	Median	All	0.698	0.320	.015	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ZNF84-DT–KIRC (DFS)

Open the KIRC breakdown →