ZNF839

Across TCGA patient cohorts, ZNF839 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF839-associated genes across cancer lineages are PEA-15_pS116, Caspase-7-cleavedD198, and Caspase-8. Each is linked with ZNF839 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF839-to-partner and partner-to-ZNF839 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PEA-15_pS116 grouped by ZNF839-low versus ZNF839-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF839→partner) and Y-score (partner→ZNF839) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PEA-15_pS116 →	+0.300	+1.584	.007	.017	3	2
UCEC	Caspase-7-cleavedD198 →	+0.606	+1.604	.001	.021	3	2
UCEC	Caspase-8 →	-0.230	-2.060	.004	.004	3	2
UCEC	eEF2 →	+0.362	+2.058	.001	<.001	3	1
UCEC	EGFR_pY1068 →	-0.242	-2.378	.002	<.001	3	1
UCEC	ERK2 →	+0.211	+2.415	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

PEA-15_pS116 by ZNF839 expression — UCEC

Explore this box plot interactively →