ZNF831

Across TCGA pan-cancer cohorts, ZNF831 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated ZNF831 data layer compared with 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZNF831 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ZNF831 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and CESC are the cancer types where ZNF831 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.424	0.289	<.001	142	view →
SKCM	OS	Median	All	0.442	0.243	<.001	109	view →
CESC	OS	Median	All	0.890	0.703	<.001	92	view →
LUAD	OS	Median	All	0.757	0.618	<.001	86	view →
UVM	DFS	Quartile	All	0.295	0.748	<.001	66	view →
BRCA	DFS	Tertile	All	0.616	0.481	.001	58	view →
LIHC	DFS	Tertile	All	0.698	0.481	<.001	57	view →
OV	OS	Tertile	II,III,IV	0.431	0.316	.006	48	view →
UCEC	OS	Quartile	All	0.815	0.529	.002	46	view →
SCLC	DFS	Quartile	III,IV	0.731	0.225	<.001	42	view →
PAAD	DFS	Median	All	0.463	0.260	.003	37	view →
BLCA	OS	Median	IV	0.755	0.386	.005	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

ZNF831–HNSC (OS)

Open the HNSC breakdown →