ZNF83

Across TCGA patient cohorts, ZNF83 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF83-associated genes across cancer lineages are PCNA, PDCD4, and STAT3_pY705. Each is linked with ZNF83 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF83-to-partner and partner-to-ZNF83 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by ZNF83-low versus ZNF83-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF83→partner) and Y-score (partner→ZNF83) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.197	+1.906	.012	.015	3	2
UCEC	PDCD4 →	-0.494	-2.247	.004	.001	3	2
UCEC	STAT3_pY705 →	-0.336	-1.807	<.001	.024	3	2
UCEC	Caspase-7-cleavedD198 →	+0.735	+1.720	<.001	.025	3	2
UCEC	A-Raf_pS299 →	-0.117	-1.847	.007	.008	3	1
UCEC	FoxM1 →	+0.223	+1.847	.019	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

PCNA by ZNF83 expression — UCEC

Explore this box plot interactively →