ZNF83

Across TCGA cell cohorts, ZNF83 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF83-associated genes across cancer lineages are PPP1R17, SLC17A6, and SPZ1. Each is linked with ZNF83 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF83-to-partner and partner-to-ZNF83 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP1R17 grouped by ZNF83-low versus ZNF83-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF83→partner) and Y-score (partner→ZNF83) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PPP1R17 →	+0.048	+2.560	<.001	.008	3	1
LARGE_INTESTINE	SLC17A6 →	+0.008	+2.977	<.001	.006	3	1
BREAST	SPZ1 →	+0.020	+3.963	<.001	.003	3	1
BREAST	TMEM174 →	+0.015	+3.672	<.001	.006	3	1
BLOOD_Leukemia	CSHL1 →	+0.026	+4.539	<.001	.007	3	1
LARGE_INTESTINE	CAMK1 →	+1.361	+3.064	.001	.009	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

PPP1R17 by ZNF83 expression — LARGE_INTESTINE

Explore this box plot interactively →