ZNF827

Across TCGA pan-cancer cohorts, ZNF827 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ZNF827 data layer compared with 27 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher ZNF827 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF827 expression acts as an unfavorable survival marker, although some lineages such as STAD show a favorable association.

CESC, HNSC, and STAD are the cancer types where ZNF827 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	III,IV	0.053	0.729	<.001	28	view →
HNSC	OS	Median	II,III,IV	0.240	0.720	<.001	24	view →
STAD	DFS	Median	II,III,IV	1.000	0.343	.034	10	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ZNF827–CESC (DFS)

Open the CESC breakdown →