ZNF827

Across TCGA pan-cancer cohorts, ZNF827 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZNF827 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ZNF827 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ZNF827 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, HNSC, and LSCC are the cancer types where ZNF827 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.965	0.750	<.001	38	view →
HNSC	DFS	Median	All	0.388	1.000	.007	17	view →
LSCC	DFS	Tertile	II,III,IV	0.467	0.829	.006	9	view →
LUAD	DFS	Quartile	All	0.803	0.939	.015	2	view →
CCRCC	DFS	Median	III,IV	0.390	1.000	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ZNF827–UCEC (DFS)

Open the UCEC breakdown →