ZNF827

Across TCGA patient cohorts, ZNF827 mutation is significantly associated with the RNA expression of many other genes, with 5,033 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF827-associated genes across cancer lineages are DEPDC1, OIP5, and PSMD9. Each is linked with ZNF827 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF827-to-partner and partner-to-ZNF827 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEPDC1 grouped by ZNF827-low versus ZNF827-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF827→partner) and Y-score (partner→ZNF827) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DEPDC1 →	+0.597	+1.868	<.001	<.001	3	4
LUAD	OIP5 →	+0.869	+3.205	<.001	.009	3	3
LUAD	PSMD9 →	+0.377	+3.854	<.001	<.001	3	3
LUAD	FOXM1 →	+1.089	+3.333	.001	.005	3	3
LUAD	RFC5 →	+0.652	+3.830	<.001	<.001	3	3
LUAD	GPSM2 →	+0.558	+2.723	.006	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,033 associations by consensus.

DEPDC1 by ZNF827 expression — UCEC

Explore this box plot interactively →