ZNF827

Across TCGA patient cohorts, ZNF827 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF827-associated genes across cancer lineages are ATM, PCNA, and CD20. Each is linked with ZNF827 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF827-to-partner and partner-to-ZNF827 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ZNF827-low versus ZNF827-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF827→partner) and Y-score (partner→ZNF827) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ATM →	-0.521	-3.169	.004	.017	3	3
UCEC	PCNA →	+0.208	+1.459	.002	.012	3	3
BLCA	CD20 →	+0.153	+2.833	.002	.034	3	2
UCEC	14-3-3_beta →	-0.100	-2.195	.002	.009	3	2
UCEC	EGFR_pY1068 →	-0.208	-1.716	.010	.003	3	2
UCEC	ERK2 →	+0.150	+2.115	.016	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

ATM by ZNF827 expression — SKCM

Explore this box plot interactively →