ZNF827

Across TCGA cell cohorts, ZNF827 mutation is significantly associated with the mutation status of many other genes, with 2,953 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF827-associated genes across cancer lineages are RTN4, CERT1, and CACTIN. Each is linked with ZNF827 in more than 4 cancer types. Because this analysis shows association rather than direction, both ZNF827-to-partner and partner-to-ZNF827 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RTN4 grouped by ZNF827-low versus ZNF827-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF827→partner) and Y-score (partner→ZNF827) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RTN4 →	+3.133	+3.000	.003	.003	1	5
BLOOD_Leukemia	CERT1 →	+4.560	+4.309	.007	.007	1	4
BLOOD_Leukemia	CACTIN →	+2.823	+3.665	.008	.008	1	4
BLOOD_Leukemia	FGFR2 →	+4.145	+4.635	.001	.001	1	4
LARGE_INTESTINE	ASIC4 →	+2.313	+2.056	.005	.005	1	4
CNS	SETD1B →	+2.740	+4.237	.007	.007	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,953 associations by consensus.

RTN4 by ZNF827 expression — SKIN

Explore this box plot interactively →