ZNF816

Across TCGA patient cohorts, ZNF816 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF816-associated genes across cancer lineages are eIF4E, GAPDH, and MEK1. Each is linked with ZNF816 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF816-to-partner and partner-to-ZNF816 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ZNF816-low versus ZNF816-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF816→partner) and Y-score (partner→ZNF816) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.184	+3.335	.015	.005	3	2
UCEC	GAPDH →	+0.402	+2.459	.037	.018	3	2
UCEC	MEK1 →	+0.439	+3.169	<.001	<.001	3	2
UCEC	Notch1 →	+0.148	+2.009	.003	.017	3	2
UCEC	N-Ras →	-0.092	-1.571	.032	.019	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.386	-1.906	.017	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

eIF4E by ZNF816 expression — UCEC

Explore this box plot interactively →