Across TCGA pan-cancer cohorts, ZNF816-ZNF321P RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated ZNF816-ZNF321P data layer compared with 2 for mutation status.
The strongest signal is observed in kidney chromophobe (KICH), where higher ZNF816-ZNF321P RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF816-ZNF321P expression acts as an unfavorable survival marker, although some lineages such as BRCA and ACC show a favorable association.
KICH, HNSC, and BRCA are the cancer types where ZNF816-ZNF321P RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.