Across TCGA patient cohorts, ZNF814 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF814-associated genes across cancer lineages are PKC-delta_pS664, EGFR_pY1068, and MEK1. Each is linked with ZNF814 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF814-to-partner and partner-to-ZNF814 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF814→partner) and Y-score (partner→ZNF814) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	PKC-delta_pS664 →	-0.158	-2.984	.016	.034	3	2
UCEC	EGFR_pY1068 →	-0.251	-1.807	.003	.004	3	2
UCEC	MEK1 →	+0.346	+1.807	.005	.004	3	2
UCEC	Notch1 →	+0.175	+2.920	<.001	<.001	3	2
UCEC	PDCD4 →	-0.619	-2.807	<.001	.002	3	2
COAD	Shc_pY317 →	-0.226	-2.991	.009	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Exploration

ZNF814 survival (RNA) · tumor vs normal (RNA) · all ZNF814 data types