Across TCGA patient cohorts, ZNF81 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF81-associated genes across cancer lineages are MSH2, p62 Lck ligand, and cIAP. Each is linked with ZNF81 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF81-to-partner and partner-to-ZNF81 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF81→partner) and Y-score (partner→ZNF81) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.213	-1.321	.002	.012	3	2
UCEC	p62 Lck ligand →	+0.321	+2.331	.001	<.001	3	2
UCEC	cIAP →	+0.107	+1.781	.009	<.001	3	2
UCEC	14-3-3_beta →	-0.092	-1.899	.002	.004	3	1
UCEC	eEF2 →	+0.260	+1.584	.016	.032	3	1
UCEC	EGFR_pY1068 →	-0.306	-3.999	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Exploration

ZNF81 survival (RNA) · tumor vs normal (RNA) · all ZNF81 data types