ZNF804B

Across TCGA pan-cancer cohorts, ZNF804B Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ZNF804B data layer compared with 13 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher ZNF804B Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF804B expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

READ, UCEC, and PRAD are the cancer types where ZNF804B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	All	0.480	0.919	<.001	30	view →
UCEC	DFS	Median	II,III,IV	0.867	0.299	.008	22	view →
PRAD	OS	Median	All	0.781	0.990	<.001	12	view →
LUAD	DFS	Median	IV	0.753	0.282	.038	4	view →
STAD	OS	Median	IV	0.111	0.433	.002	3	view →
SKCM	DFS	Median	II,III,IV	0.864	0.671	.027	3	view →
LUSC	OS	Median	II,III,IV	0.490	0.650	.027	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ZNF804B–READ (OS)

Open the READ breakdown →