ZNF804A

Across TCGA pan-cancer cohorts, ZNF804A Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated ZNF804A data layer compared with 18 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ZNF804A Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated ZNF804A expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

UCEC, LUAD, and KIRP are the cancer types where ZNF804A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.955	0.608	.001	36	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	12	view →
KIRP	OS	Median	II,III,IV	0.188	0.771	.016	10	view →
SARC	DFS	Median	All	0.101	0.632	.011	6	view →
PRAD	DFS	Median	All	0.617	0.886	.011	6	view →
DLBC	OS	Median	All	0.054	0.842	<.001	6	view →
ESCA	OS	Median	II,III,IV	0.105	0.867	.016	6	view →
SCLC	OS	Median	II,III,IV	0.274	0.883	.007	3	view →
LUSC	DFS	Median	All	0.925	0.755	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

ZNF804A–UCEC (DFS)

Open the UCEC breakdown →