ZNF80

Across TCGA patient cohorts, ZNF80 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF80-associated genes across cancer lineages are TFRC, EGFR_pY1068, and A-Raf_pS299. Each is linked with ZNF80 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF80-to-partner and partner-to-ZNF80 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by ZNF80-low versus ZNF80-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF80→partner) and Y-score (partner→ZNF80) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TFRC →	+0.634	+3.000	.017	.035	3	3
UCEC	EGFR_pY1068 →	-0.304	-2.321	.003	.006	3	2
UCEC	A-Raf_pS299 →	-0.132	-2.321	.007	.034	3	2
UCEC	MEK1 →	+0.556	+3.807	<.001	<.001	3	2
UCEC	MSH2 →	-0.279	-1.807	.003	.027	3	2
UCEC	MSH6 →	-0.388	-3.169	.004	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

TFRC by ZNF80 expression — SKCM

Explore this box plot interactively →