ZNF8

Across TCGA pan-cancer cohorts, ZNF8 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZNF8 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZNF8 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF8 expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

HNSC, PDAC, and LSCC are the cancer types where ZNF8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	IV	0.508	0.967	.002	29	view →
PDAC	DFS	Median	III,IV	0.389	0.905	.005	21	view →
LSCC	OS	Median	All	1.000	0.938	.012	11	view →
UCEC	DFS	Median	All	1.000	0.936	.021	6	view →
CCRCC	DFS	Median	II,III,IV	1.000	0.638	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ZNF8–HNSC (OS)

Open the HNSC breakdown →