ZNF8

Across TCGA patient cohorts, ZNF8 mutation is significantly associated with the RNA expression of many other genes, with 561 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF8-associated genes across cancer lineages are MIR8081, RPS6P4, and BANF2. Each is linked with ZNF8 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF8-to-partner and partner-to-ZNF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR8081 grouped by ZNF8-low versus ZNF8-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF8→partner) and Y-score (partner→ZNF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR8081 →	+0.167	+3.917	<.001	.009	3	3
HNSC	RPS6P4 →	+0.065	+5.655	<.001	.004	3	2
CESC	BANF2 →	+0.055	+2.975	.001	.002	3	2
CESC	PSAT1P1 →	+0.047	+2.797	.002	.004	3	2
CESC	MIR3691 →	+0.280	+3.669	<.001	.003	3	2
UCEC	ACP3 →	-0.704	-2.890	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 561 associations by consensus.

MIR8081 by ZNF8 expression — COAD

Explore this box plot interactively →