ZNF8

Across TCGA cell cohorts, ZNF8 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF8-associated genes across cancer lineages are SMIM33, LUZP4, and HRG. Each is linked with ZNF8 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF8-to-partner and partner-to-ZNF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMIM33 grouped by ZNF8-low versus ZNF8-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF8→partner) and Y-score (partner→ZNF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SMIM33 →	+0.011	+3.807	<.001	.003	3	1
BLOOD_Leukemia	LUZP4 →	+0.455	+4.060	<.001	.003	3	1
BLOOD_Leukemia	HRG →	+0.332	+3.855	<.001	.007	3	1
BLOOD_Leukemia	MAGEA9 →	+0.159	+4.339	<.001	.002	3	1
BLOOD_Leukemia	FBP2 →	+0.206	+3.769	.003	.008	3	1
BLOOD_Leukemia	USP26 →	+0.023	+4.786	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

SMIM33 by ZNF8 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →