Across TCGA patient cohorts, ZNF777 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF777-associated genes across cancer lineages are Caspase-7-cleavedD198, LKB1, and SCD. Each is linked with ZNF777 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF777-to-partner and partner-to-ZNF777 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF777→partner) and Y-score (partner→ZNF777) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+1.046	+2.107	<.001	.002	3	3
SKCM	LKB1 →	+0.193	+3.169	.002	.019	3	2
SKCM	SCD →	+0.229	+3.169	.003	.019	3	2
SKCM	Claudin-7 →	+0.186	+3.204	.022	.009	2	3
UCEC	FoxM1 →	+0.184	+2.469	.043	.010	3	2
UCEC	MEK1 →	+0.461	+2.392	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Exploration

ZNF777 survival (RNA) · tumor vs normal (RNA) · all ZNF777 data types