Across TCGA patient cohorts, ZNF774 mutation is significantly associated with the RNA expression of many other genes, with 1,045 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF774-associated genes across cancer lineages are MIR3182, RNA5SP198, and RNU6-497P. Each is linked with ZNF774 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF774-to-partner and partner-to-ZNF774 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF774→partner) and Y-score (partner→ZNF774) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR3182 →	+0.945	+5.435	<.001	.005	3	2
CESC	RNA5SP198 →	+0.305	+5.144	<.001	.003	3	2
LUSC	RNU6-497P →	+0.402	+6.666	<.001	<.001	3	2
LUSC	MIR4282 →	+0.316	+5.309	<.001	.003	3	2
UCEC	GABBR1 →	-0.888	-3.169	.001	<.001	3	2
UCEC	MIR181A1 →	+0.177	+2.951	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,045 associations by consensus.

Exploration

ZNF774 survival (RNA) · tumor vs normal (RNA) · all ZNF774 data types