Across TCGA patient cohorts, ZNF774 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF774-associated genes across cancer lineages are 14-3-3_beta, MSH2, and P-Cadherin. Each is linked with ZNF774 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF774-to-partner and partner-to-ZNF774 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF774→partner) and Y-score (partner→ZNF774) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.095	-2.295	.015	.033	3	2
UCEC	MSH2 →	-0.259	-3.558	.004	.002	3	1
UCEC	P-Cadherin →	-0.119	-2.321	.036	.033	3	1
UCEC	Rab25 →	-0.459	-2.000	<.001	.010	3	1
UCEC	Annexin-1 →	+0.521	+2.502	.011	.002	3	1
UCEC	SETD2 →	-0.195	-2.000	.022	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

ZNF774 survival (RNA) · tumor vs normal (RNA) · all ZNF774 data types