ZNF768

Across TCGA patient cohorts, ZNF768 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF768-associated genes across cancer lineages are CDK1, ERK2, and MEK1. Each is linked with ZNF768 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF768-to-partner and partner-to-ZNF768 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDK1 grouped by ZNF768-low versus ZNF768-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF768→partner) and Y-score (partner→ZNF768) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDK1 →	+0.167	+2.820	.027	.035	3	2
UCEC	ERK2 →	+0.298	+2.321	.002	.035	2	2
UCEC	MEK1 →	+0.456	+2.321	.013	.035	3	1
UCEC	NF2 →	+0.292	+3.000	.007	.036	3	1
UCEC	p62 Lck ligand →	+0.469	+3.009	.004	.019	3	1
UCEC	SETD2 →	-0.277	-3.169	.011	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

CDK1 by ZNF768 expression — UCEC

Explore this box plot interactively →