ZNF761

Across TCGA patient cohorts, ZNF761 mutation is significantly associated with the RNA expression of many other genes, with 6,469 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF761-associated genes across cancer lineages are SKA1, CCNB2, and H2AZ1. Each is linked with ZNF761 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF761-to-partner and partner-to-ZNF761 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKA1 grouped by ZNF761-low versus ZNF761-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF761→partner) and Y-score (partner→ZNF761) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SKA1 →	+0.785	+2.162	<.001	<.001	3	4
UCEC	CCNB2 →	+0.762	+2.152	<.001	<.001	3	4
UCEC	H2AZ1 →	+0.688	+2.389	<.001	<.001	3	4
UCEC	PSMD8 →	+0.302	+1.645	.001	<.001	3	4
UCEC	NDUFC1 →	+0.390	+1.984	<.001	<.001	3	4
UCEC	CKS2 →	+0.774	+2.584	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,469 associations by consensus.

SKA1 by ZNF761 expression — UCEC

Explore this box plot interactively →